Host-Pathogen Kinetics of Viral and Bacterial Infections and Coinfections
● Model-Driven Experimentation ● Data-Driven Modeling ●
● Infection Dynamics ● Integrative Analysis ●
● Mathematical Virology, Bacteriology, and Immunology ●
We study host-pathogen interactions using an integrated approach that combines data-driven mathematical models and model-driven experiments. We specialize in developing and calibrating mathematical models of viral, bacterial, and host immune kinetics using high-quality, quantitative data. We then design and carry out experiments to test our analytical predictions. We use this method to understand the complex pathogen and immune dynamics during viral infections, bacterial infections, and multi-pathogen coinfections.
Dr. Amber Smith, Ph.D. is an Associate Professor in the Department of Pediatrics and the Institute for the Study of Host-Pathogen Systems at the University of Tennessee Health Science Center.
Recent Publications
Schughart K, Smith AM , Tsalik EL, Threlkeld SC, Sellers S, Fischer WA, Schreiber J, Lücke E, Cornberg M, Debarry J, Woods CW, Mcclain MT, Heise M (2024). Host response to influenza infections in human blood: Association of influenza severity with host genetics and transcriptomic response . (submitted).
Weaver JJA, Smith AM* (2023). Quantitatively mapping immune control during influenza. Current Opinion in Systems Biology 38: 100516. doi: 10.1016/j.coisb.2024.100516
Laubenbacher R*, [14 co-authors], Smith AM, Voigt I, Yankeelov TE, Ziemssen T (2024). Toward mechanistic digital twins: Some use cases in immunology. Frontiers in Digital Health 6:1349595. doi: 10.3389/fdgth.2024.1349595
Malik-Sheriff RS*, Asari H, Hermjakob H, Huber W, Quail T, Santos SDM, Smith AM, Uhlmann V (2024). BioModels Model of the Year 2023. Frontiers Sys Biol. doi: 10.3389/fsysb.2024.1363884
Laubenbacher R*, [14 co-authors], Smith AM, Voigt I, Yankeelov TE, Ziemssen T. (2024). Forum on immune digital twins: a meeting report. npj Systems Biology and Applications 10(19). doi: 10.1038/s41540-024-00345-5
Pinky L, DeAguero JR, Remien CH, Smith AM. (2023). How interactions during viral-viral coinfection can shape infection kinetics. Viruses 15(6):1303.
2014 Editorial
Laboratory of Amber Smith 