Host-Pathogen Kinetics of Influenza-Pneumococcal Coinfections
● Model-Driven Experimentation ● Data-Driven Modeling ●
● Infection Dynamics ● Integrative Analysis ●
● Mathematical Virology, Bacteriology, and Immunology ●
We study host-pathogen interactions using an integrated approach that combines data-driven mathematical models and model-driven experiments. We specialize in developing and calibrating mathematical models of viral, bacterial, and host immune kinetics using high-quality, quantitative data. We then design and carrying out experiments to test our analytical predictions. We use this method to understand the complex pathogen and immune dynamics during influenza virus infections, pneumococcal infections, and influenza-pneumococcal coinfections.
Dr. Amber Smith, Ph.D. is a faculty member in Infectious Diseases at St. Jude Children’s Research Hospital. She is a quantitative biologist trained in both Applied Mathematics and Experimental Microbiology and Immunology. She received her Ph.D. from the University of Utah in 2009 under the mentorship of Dr. Fred Adler. She did her postdoctoral training at the Los Alamos National Laboratory with Dr. Alan Perelson and at St. Jude Children’s Research Hospital with Dr. Jon McCullers.
A.M. Smith* and A.P. Smith (2016). A Critical, Nonlinear Threshold Dictates Bacterial Invasion and Initial Kinetics During Influenza. Sci Rep, 6, 38703, doi:10.1038/srep38703
A.M. Smith* (2016). Quantifying the Therapeutic Requirements and Potential for Combination Therapy to Prevent Bacterial Coinfection During Influenza. J Pharmacokinet Pharm doi:10.1007/s10928-016-9494-9