Host-Pathogen Kinetics of Influenza-Pneumococcal Coinfections
● Model-Driven Experimentation ● Data-Driven Modeling ●
● Infection Dynamics ● Integrative Analysis ●
● Mathematical Virology, Bacteriology, and Immunology ●
We study host-pathogen interactions using an integrated approach that combines data-driven mathematical models and model-driven experiments. We specialize in developing and calibrating mathematical models of viral, bacterial, and host immune kinetics using high-quality, quantitative data. We then design and carrying out experiments to test our analytical predictions. We use this method to understand the complex pathogen and immune dynamics during influenza virus infections, pneumococcal infections, and influenza-pneumococcal coinfections.
Dr. Amber Smith, Ph.D. is an Assistant Professor in the Department of Pediatrics and the Institute for the Study of Host-Pathogen Systems at the University of Tennessee Health Science Center. She is a quantitative biologist trained in both Applied Mathematics and Experimental Microbiology and Immunology. She received her Ph.D. from the University of Utah in 2009 under the mentorship of Dr. Fred Adler. She did her postdoctoral training at the Los Alamos National Laboratory with Dr. Alan Perelson and at St. Jude Children’s Research Hospital with Dr. Jon McCullers.
M. Chung, M. Binois, R.B. Gramacy, D.J. Moquin, A.P. Smith and A.M. Smith (2018). Parameter and Uncertainty Estimation for Dynamical Systems Using Surrogate Stochastic Processes. (submitted) Preprint
A.P. Smith, D.J. Moquin, V. Bernhauerova, and A.M. Smith* (2018). Influenza Virus Infection Model with Density Dependence Supports Biphasic Viral Decay. (submitted) Preprint
A. Rodriguez, J.A. McCullers, A.M. Smith*, T. Kanneganti, C.R. Lupfer (2018). Enhanced priming of IL-1β contributes to immunopathology during coinfection with influenza A virus and Streptococcus pneumoniae. (submitted)
A.M. Smith* and V.C. Huber* (2017). The Unexpected Impact of Vaccines on Secondary Bacterial Infections Following Influenza. Viral Immunology doi:10.1089/vim.2017.0138
A.M. Smith* and A.P. Smith (2016). A Critical, Nonlinear Threshold Dictates Bacterial Invasion and Initial Kinetics During Influenza. Sci Rep, 6, 38703, doi:10.1038/srep38703
A.M. Smith* (2016). Quantifying the Therapeutic Requirements and Potential for Combination Therapy to Prevent Bacterial Coinfection During Influenza. J Pharmacokinet Pharm doi:10.1007/s10928-016-9494-9